Intracellular Condensates of Oligopeptide for Targeting Lysosome and Addressing Multiple Drug Resistance of Cancer (Adv. Mater. 1/2022)

Artificial Biomolecular Condensates In article number 2104704, Huaimin Wang and co-workers report a general approach for constructing artificial biomolecular condensates of oligopeptide in living cells. The rationally designed aromatic-capped peptides can reversibly form nanofibrous hydrogel with change the conformation morphologies lysosome. formed undergo swelling lysosome, leading to lysosomal membrane permeabilization re-direction therapeutic drugs target.